Fig. 3: Functional connectivity: correlation with CRP and mediation analysis. | Molecular Psychiatry

Fig. 3: Functional connectivity: correlation with CRP and mediation analysis.

From: Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks

Fig. 3

A Cortical maps highlighting edges between regional nodes defined by significant correlation of functional connectivity with CRP (FDR corrected at 0.05 and 0.1). B Mediation analysis of the direct effect of CRP on PD in posterior cingulate cortical area POS1, the direct effect of CRP on functional connectivity between POS1 and hippocampus (represented by the red edge between nodes in the brain map), and the effect of PD on POS1-hippocampal connectivity. The direct effects of CRP on POS1 PD and hippocampal connectivity are significant but there is no indirect effect of CRP on hippocampal connectivity mediated by its effect on PD in posterior cingulate cortex. C Mediation analysis of the direct effect of CRP on PD in posterior cingulate cortical areas d23ab and 31pv, the direct effect of CRP on functional connectivity between d23ab/31pv and medial frontal area a32pr (represented by the blue edge between nodes in the brain map), and the effect of PD on d23ab/31pv-hippocampal connectivity. The direct effect of CRP on d23ab/31pv PD and there is an indirect effect of CRP on medial prefrontal connectivity mediated by its effect on PD in posterior cingulate cortex. (ACME: average causal mediation effect, ADE: average direct effect).

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