Fig. 5: Summary of the progression of changes during the maturation of IQSEC2-mutant vs. control neurons. | Molecular Psychiatry

Fig. 5: Summary of the progression of changes during the maturation of IQSEC2-mutant vs. control neurons.

From: IQSEC2 mutation associated with epilepsy, intellectual disability, and autism results in hyperexcitability of patient-derived neurons and deficient synaptic transmission

Fig. 5

a The total number of evoked action potentials is higher in the IQSEC2-mutant neurons than the controls at 5 weeks and is decreased at 11 weeks compared to control neurons. b Similarly, the Max number of action potentials is higher in the IQSEC2-mutant neurons at 5 weeks and later decreases below the controls at 11 weeks. Both these measures in (a) and (b) represent neuronal excitability. c At 5 and 7 weeks the fast AHP amplitude is increased in the IQSEC2-mutant neurons, and at 11 weeks the fast AHP is similar between control and IQSEC2-mutant neurons. d The spike amplitude is larger at all time points in the IQSEC2-mutant neurons. e The spike width (Full Width at Half the Maximum—FWHM) is narrower in the IQSEC2-mutant neurons at 5 weeks and 7 weeks but is similar to the controls at 11 weeks. f The spike threshold is similar between the IQSEC2-mutant neurons and the control neurons at all-time points. g The capacitance is similar between the IQSEC2-mutant neurons and the control neurons at all-time points. h The rate of excitatory postsynaptic currents (EPSCs) starts very low in both IQSEC2-mutant and wild-type neurons and increases significantly at 11 weeks. This rate is reduced in the IQSEC2-mutant neurons at 11 weeks when compared to the control neurons.

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