Fig. 5: Modified RNAs are present in situ at pre- and post- synaptic sites within CA3/CA4 neurons. | Molecular Psychiatry

Fig. 5: Modified RNAs are present in situ at pre- and post- synaptic sites within CA3/CA4 neurons.

From: Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging

Fig. 5

A, B STEM imaging indicates m6A modified RNAs at both at the postsynaptic compartment (coloured blue and shown by the yellow arrow), presynaptic terminals (coloured green) and in processes (orange). C, D YTHDF1 was found clustered within the presynaptic region (green) whilst in the postsynaptic sites (blue) the protein is more distributed and located at both postsynaptic terminals near to the active zone as well as throughout the bouton.YTHDF1 was also abundant within dendritic spines (pink). The structure evident on the left hand side of A and B is the amorphous carbon support film.

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