Fig. 4: Rnd2 deletion impacts directly the survival of adult-born DGNs during a specific period of their development. | Molecular Psychiatry

Fig. 4: Rnd2 deletion impacts directly the survival of adult-born DGNs during a specific period of their development.

From: The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis

Fig. 4

A, F Experimental designs. A retrovirus expressing GFP together with a conditionally active form of Cre recombinase, which is activated upon tamoxifen, was injected into the DG of adult Rnd2flox/flox mice. Three (A) or eight weeks (F) after virus injection, tamoxifen (150 mg/kg, daily for five days), or oil in control group, was injected, and animals were sacrificed 21 days after the last injection of tamoxifen. dpi days post injection. B–E, G–J The relative number of GFP+ cells, the relative position in the GCL, and the morphology of transduced cells were quantified 21 days after the last injection of tamoxifen. Mean ± s.e.m., Unpaired two-tailed Student’s t-test; *p < 0.05 (n = 7 animals per group). See also Supplementary Fig.  8.

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