Fig. 6: Rnd2 deletion in adult-born DGNs increases anxiety-like behavior. | Molecular Psychiatry

Fig. 6: Rnd2 deletion in adult-born DGNs increases anxiety-like behavior.

From: The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis

Fig. 6

A Time spent in the open arms (in % of time spent in the open arms and in the closed arms) and (B) number of total entries in the elevated plus maze (EPM), four (EPM1) or 10 weeks (EPM2) after GFP or GFP/Cre retrovirus injection. Mean ± s.e.m., Unpaired two-tailed Student’s t-test; *p < 0.05. C Time to escape and (D) time spent in the lit area in the light/dark test, five weeks after retroviral injection. Mean ± s.e.m., Unpaired two-tailed Student’s t-test; *p < 0.05, ***p < 0.001. E z-anxiety score calculated by averaging z-score values of the different tests used to assess anxiety-like behavior. An increased score value reflects increased anxiety. Mean ± s.e.m., Unpaired two-tailed Student’s t-test; ***p < 0.001. See also Supplementary Figs. 10–11.

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