Fig. 4: Neutral sphingomyelinase controls osteocalcin (OST) release. | Molecular Psychiatry

Fig. 4: Neutral sphingomyelinase controls osteocalcin (OST) release.

From: Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

Fig. 4

OST limits alcohol consumption and has beneficial effects on emotional behaviour. a Blood OST levels are upregulated in mice with reduced neutral sphingomyelinase (NSM) activity (fro) (n = 6 per group). Data are expressed as means + s.e.m. (*P < 0.05 vs. wild type (WT). b Chronic administration of OST (0.03 µg/30 g/h, s.c.) in naive C57Bl6J mice for 28 days via osmotic mini pumps attenuated alcohol consumption in a two-bottle free-choice test, but (c) did not affect total fluid intake (n = 8 per group). d–g Chronic OST had no effect on anxiety-related behaviour in mice in the elevated plus maze (EPM) or open field (OF) tests, but (h) reduced depression-like behaviour in the novelty suppressed feeding test (NSF) (n = 7–8 per group). Data are expressed as means ± s.e.m. (*P < 0.05, vs. vehicle (veh) control; OA open arm).

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