Fig. 4: Cognitive deficits and symptom severity in relation to the stratification based on the combined detection of miR-137 and COX6A2 levels. | Molecular Psychiatry

Fig. 4: Cognitive deficits and symptom severity in relation to the stratification based on the combined detection of miR-137 and COX6A2 levels.

From: Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia

Fig. 4

(A Boxplots displaying neurocognitive domains (speed processing, attention/vigilance, working memory, problem-solving and verbal and visual learning) according to the stratification Psy-D (with mitochondrial dysfunction) and Psy-ND (with no/low mitochondrial dysfunction). Psy-D subjects exhibit worse performance in cognitive tests than Psy-ND subjects and healthy controls. B Correlations between neurocognitive and functional profiles and exosomal levels of miR-137 and COX6A2. C Psy-D individuals displayed lower GAF, and SOFAS scores than Psy-ND individuals. D Psy-D subjects presented more symptoms on the PANSS scale than Psy-ND psychosis subjects. E Exosomal levels of miR-137 in the Psy-D individuals (red dots) positively correlated with symptoms severity while Psy-ND (empty circles) do not. F Exosomal levels of COX6A2 in the Psy-D individuals negatively correlated with symptoms severity. p < 0.001***, p < 0.01**, p < 0.05*, p < 0.07Δ.

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