Fig. 1: Schematic representation of the concept proposed in this paper, showing the reciprocal interaction between mitochondria, NMDAR, neuro-immune system, dopamine on one hand and the complex redox regulation/oxidative stress (OxS) on the other. | Molecular Psychiatry

Fig. 1: Schematic representation of the concept proposed in this paper, showing the reciprocal interaction between mitochondria, NMDAR, neuro-immune system, dopamine on one hand and the complex redox regulation/oxidative stress (OxS) on the other.

From: Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia

Fig. 1

Irrespectively of which is the primary affected system via genetic or environmental factors, this will trigger during development subsequent vicious circles of OxS that can feed on one another and drive durably parvalbumin (PV) neurons and myelin impairments that culminate in the neural synchronization and cognitive deficits characteristic of schizophrenia.

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