Table 1 IntelliCage-based cognitive and emotional testing.
(A) Mice immunized with GluN1 extracellular peptides (NR1) or ovalbumin (OVA) | ||||||||
|---|---|---|---|---|---|---|---|---|
Group 1 | Group 2 | Group 3 | Comparison | |||||
WT + NR1 | Cnp−/− + OVA | Cnp−/− + NR1 | Across groups | |||||
Mean ± SEM | n | Mean ± SEM | n | Mean ± SEM | n | Test | p value | |
IntelliCage-based behavioral test battery | ||||||||
Place learning − place errors [% of corner visits] | 67.89 ± 1.6 | 14 | 70.98 ± 1.1 | 13 | 71.49 ± 1.1 | 13 | Welch’s ANOVA | 0.207 |
Reversal learning − place errors [% of corner visits] | 66.25 ± 1.7 | 14 | 70.01 ± 1.7 | 13 | 71.18 ± 1.1 | 13 | Kruskal–Wallis | 0.087 |
Sucrose preference − delta [sucrose − water] | 15.68 ± 3.5 | 14 | 15.38 ± 2.8 | 13 | 14.45 ± 2.7 | 13 | Kruskal–Wallis | 0.673 |
(B) Mice with oligodendrocyte-specific deletion of NR1 | ||||||
|---|---|---|---|---|---|---|
Group 1 | Group 2 | Comparison | ||||
NR1flox/flox | CnpCre+/−*NR1flox/flox | Group 1 versus Group 2 | ||||
Mean ± SEM | n | Mean ± SEM | n | Test | p value | |
IntelliCage-based behavioral test battery | ||||||
Place learning − place errors [% of corner visits] | 68.37 ± 1.2 | 15 | 69.70 ± 1.3 | 14 | t | 0.463 |
Reversal learning − place errors [% of corner visits] | 62.21 ± 1.7 | 15 | 68.94 ± 1.7 | 14 | t | 0.011 |
Sucrose preference − delta [sucrose − water] | 15.03 ± 4.4 | 15 | 10.29 ± 2.7 | 14 | t | 0.373 |
