Fig. 1: Identification of nORFs within neuropsychiatric samples. | Molecular Psychiatry

Fig. 1: Identification of nORFs within neuropsychiatric samples.

From: Novel open reading frames in human accelerated regions and transposable elements reveal new leads to understand schizophrenia and bipolar disorder

Fig. 1

A The workflow used to identify nORF containing transcripts within neuropsychiatric samples is shown. Genomic coordinate matches between nORFs and sample transcripts assessed using GffCompare, were filtered to retain only matches of the type “=” or complete intron chain overlap. Next, nORFs with exon boundaries contained within their corresponding transcript matches were selected. Finally, only non-coding transcripts, with biotype not equal to “protein-coding”, were retained for further DE analysis. B Percentage of the total nORF containing transcripts split over their biotypes shows that ~47% of transcripts are retained introns. C The 40 and 56 DE transcripts highlighted in Table 2, contain 44 and 61 nORFs for BD and SCZ, respectively. Venn diagram assessing the 44 BD and 61 SCZ nORFs shows that 14 nORFs are common to and present within DE transcripts in SCZ and BD. D For nORFs within DE transcripts, transcript biotype against total transcript percentage is shown. The highest occupancy of nORFs in DE transcripts is within retained introns followed by processed transcripts, similar to B.

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