Fig. 5: Structure prediction for translated nORFs. | Molecular Psychiatry

Fig. 5: Structure prediction for translated nORFs.

From: Novel open reading frames in human accelerated regions and transposable elements reveal new leads to understand schizophrenia and bipolar disorder

Fig. 5

A Structures were predicted for the 21 translated nORFs, 4 of which are shown here along with their nORF ids (top-left). These nORFs were found to be significantly different in BD and SCZ patients for psychosis or suicide. B Example of predicted structures for nORFs that are DE in BD (up–top-left; down–top-right) and SCZ (up–bottom-left; down–bottom-right) and were found to be associated with HARs. Additionally, the DE nORF tracer_65443 and its parent gene ZEB2 were both within an SCZ-associated locus (SNP locus that involved SNPs with p value 10−7 < P < 10−6). The parent gene (SCL7A6OS) of one DE nORF (tracer_42939) was within an SCZ-associated locus p < 10−7 and was also associated with a BD-associated SNP locus that involved SNPs with 10−5 < P < 10−4.

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