Table 5 Genes in coding hotspots and their interacted medications.
Variation type | Locus | Genes/interacted medications |
|---|---|---|
Frameshift SNVs | chr11:55000001-60000000 | TCN1 (cyanocobalamin); MED19 (alcohol) |
Frameshift SNVs | chr16:55000001-60000000 | SLC12A3 (interacted with 18 medicines); CETP (tamoxifen, atorvastatin, simvastatin, pravastatin, lovastatin, fluvastatin); MMP2 (cyclosporine, pravastatin, bevacizumab, vinblastine, filgrastim, zileuton, paclitaxel, simvastatin, letrozole, streptozocin, acetazolamide, deferoxamine, ramipril) |
Frameshift SNVs | chr19:50000001-55000000 | KIR2DS4 (methotrexate); KCNC3 (dalfampridine, guanidine hydrochloride); FPR1 (penicillin G potassium, sulfinpyrazone); KLK1 (ecallantide); PRPF31 (metformin); CACNG6 (bepridil hydrochloride, pregabalin, gabapentin enacarbil, gabapentin) |
Frameshift SNVs | chr6:30000001-35000000 | HCG22 (triamcinolone); CCHCR1 (nevirapine); HSPA1L (carbamazepine); MUCL3 (carboplatin, gemcitabine); EHMT2 (interacted with 189 medications); CDSN (carboplatin, gemcitabine); TCF19 (nevirapine); NOTCH4 (allopurinol); TAPBP (aspirin); ATAT1 (gemcitabine, carboplatin); COL11A2 (ocriplasmin, collagenase clostridium histolyticum); ZBTB22 (aspirin); TNF (interacted with 41 drug) |
Frameshift SNVs | chr7:100000001-105000000 | SERPINE1 (cetrorelix, hydrochlorothiazide, epirubicin, captopril, orlistat, levothyroxine, nimodipine, dexamethasone, defibrotide, citalopram, urokinase, fluoxetine, vasopressin); STAG3 (vemurafenib); ACHE (interacted with 28 medications); EPHB4 (vandetanib) |
Stop codon | chr11:55000001-60000000 | TMX2 (alcohol) |
Stop codon | chr17:35000001-40000000 | SLFN11 (niraparib, temozolomide, talazoparib); CCL3 (infliximab) |
Stop codon | chr19:1-5000000 | TBXA2R (morphine, iloprost, furosemide, vinblastine, dinoprostone, cyclosporine, aspirin, alprostadil); GRIN3B (felbamate, ketamine hydrochloride, esketamine, amantadine hydrochloride, orphenadrine hydrochloride, acamprosate calcium, orphenadrine, orphenadrine citrate, esketamine hydrochloride, memantine hydrochloride); PLIN3 (galsulfase, idursulfase); AMH (testosterone); MKNK2 (erlotinib, gefitinib, sorafenib); PIP5K1C (alcohol) |
Stop codon | chr19:50000001-55000000 | KIR2DS4 (methotrexate); KLK4 (ecallantide, bortezomib); CACNG6 (bepridil hydrochloride, pregabalin, gabapentin enacarbil, gabapentin); PRPF31 (metformin); NDUFA3 (metformin hydrochloride) |
