Fig. 1: Region of Interest (ROI) analysis in all patients and healthy controls. | Molecular Psychiatry

Fig. 1: Region of Interest (ROI) analysis in all patients and healthy controls.

From: Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals

Fig. 1

Dot plots demonstrating regional changes in Aβ-positive patients (purple filled circle, N = 7), Aβ-negative patients (purple open circle, N = 4) and healthy controls (green triangle, N = 9): (a) 11C-BU99008 (b) 18F-FDG (c) VBM and (d) 18F-Florbetaben. Difference in tracer uptake and GM volume between Aβ-positive patients and healthy controls was analysed using two-sample Student’s t tests (two-tailed), with statistical difference set to p < 0.05. Multiple comparison corrections were not performed on the ROI results due to the exploratory nature of this pilot study. “Whole Brain” refers to the composite cortex, combining all the four lobes and the cingulate. * denotes p < 0.05.

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