Fig. 3: Statistical Parametric Mapping (SPM) group analysis in patients compared to healthy controls. | Molecular Psychiatry

Fig. 3: Statistical Parametric Mapping (SPM) group analysis in patients compared to healthy controls.

From: Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals

Fig. 3

Rendered SPM results from two-sample Student’s t tests (two-tailed) for differences in tracer uptake and GM volume between patients (N = 11) and healthy controls (N = 9): (a) Increased 11C-BU99008 uptake in Aβ-positive patients (N = 7), rendered at cluster threshold of p < 0.05 and an extent threshold of 50 voxels. b Decreased 18F-FDG uptake in Aβ-positive patients (N = 7), rendered at cluster threshold of p < 0.001 and an extent threshold of 50 voxels. c Decreased GM volume in Aβ-positive patients (N = 7), rendered at cluster threshold of p < 0.05 and an extent threshold of 50 voxels. d Increased 18F-Florbetaben uptake in all patients (N = 11), rendered at cluster threshold of p < 0.001 and an extent threshold of 50 voxels. Coordinates for significant clusters following FWE-correction can be found in Supplementary Table 1. Colourbar units are contrast estimates representative of Z-scores.

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