Table 1 Sociodemographic data, symptoms, and laboratory parameters of COVID patients divided into three groups according to severity of sickness symptom complex (SSC).

From: In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a nomothetic network approach

Variables

COVID-19 + minSSC A n = 241

COVID-19 + modSSC B n = 152

COVID-19 + highSSC C n = 135

F/X2

df

p

Sex (female/male)

94/147C

73/79

78/57A

12.49

2

0.002

Age (years)

64.6 (16.8)B,C

58.6 (1.5)A,C

47.5 (17.3)A,B

40.77

2/525

<0.001

Number days until diagnosis (days)

6.1 (4.4)

6.4 (3.4)

7.4 (4.9)

2.39

2/403

0.093

Days from diagnosis until outcome of hospilatization (days)

15.5 (13.0)

14.4 (8.2)

14.6 (8.5)

0.45

2/401

0.641

Durion of acute phase (days)

21.6 (14.9)

20.9 (9.8)

22.0 (10.7)

0.19

2/401

0.828

Ethnicity (C/NC)

195/46

122/29

104/31

0.92

2

0.632

Smoking (N/Y)

228/13

149/3

131/4

3.33

2

0.189

Body mass index (kg/m2)

27.72 (5.80)

27.82 (5.28)

27.90 (5.59)

0.04

2/379

0.964

T2DM (on oral hypoglycemiants) (N/Y)

173/68C

114/37C

118/17A,B

12.09

2

0.002

Hypertension (N/Y)

120/121C

75/77C

100/35A,B

24.38

2

<0.001

Fatigue (N/Y)

198/42B,C

82/70A,C

37/98A,B

111.41

2

<0.001

Sickness symptom complex severity

9.36 (0.48)B,C

11.39 (0.49) A,C

14.22 (1.25) A,B

1973.23

2/525

<0.001

SARS (N/Y)

138/103B,C

110/42A,C

114/21A,B

31.10

2

<0.001

SARS severity

4.87 (0.88)B,C

4.51 (0.98)A,C

4.07 (0.89)A,B

33.07

2/525

0.415

DIIS index

0.110 (1.032)B,C

−0.118 (0.955)A

−0.192 (0.917)A

3.31

2/403

0.038

Inflammation index

−0.011 (1.112)

0.305 (1.015)

−0.020 (0.746)

0.14

2/525

0.843

C-Reactive Protein (CRP) mg/L*

126.4 (90.7)

130.9 (99.1)

121.5 (81.5)

0.03

2/525

0.975

Neutrophil/Llymphocyte ratio

10.32 (9.61)

10.63 (9.97)

10.63 (9.97)

0.24

2/525

0.791

Ferritin (ng/mL)*

1533 (3075)

1404 (1271)

4035 (20693)

2.37

3/391

0.095

CCTA

3.17 (1.20)

3.34 (1.01)

3.22 (0.71)

0.88

2/521

0.415

SpO2 (%)

87.3 (7.1)

87.9 (6.4)

87.8 (3.7)

0.59

2/525

0.557

Mild/Moderate + critical COVID-19

35/206B,C

41/111A,C

81/54A,B

86.43

2

<0.001

Intensive care unit (N/Y)

159/82C

112/40

113/22A

13.81

2

0.001

Orotracheal intubation (N/Y)

163/78C

119/33C

124/11A,B

28.80

2

<0.001

Death (N/Y)

134/95B,C

89/31A

47/10A

16.24

2

<0.001

  1. All results of Chi-square tests (X2) or analysis of variance (F). FEPT: results of Fisher’s exact probability test. Results are expressed as mean (±SD), A,B,C: multiple comparisons among treatment means, *Processed in Log transformation.
  2. C Caucasian, NC Not Caucasian, T2DM type 2 Diabetes mellitus, DIIS index first factor extracted from death, intensive care unit admission, orotracheal intubation, SARS severe acute respiratory syndrome, CCTA chest computed tomography abnormalities, SpO2 oxygen saturation percentage, Inflammation index computed as a z unit weighted composite score of z CRP + z neutrophil/lymphocyte ratio.
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