Table 3 Associations between NLRP3 inflammasome genetic variants and symptoms of severe acute respiratory syndrome (SARS) and sickness behavior.
Dependent variables | Symptoms (yes/no) | Genetic variants | B | SE | W (df = 1) | p | OR | CI 95% |
|---|---|---|---|---|---|---|---|---|
SARS | SARS | NLPR3 rs10157379 CT | 0.477 | 0.189 | 6.38 | 0.012 | 1.61 | 1.11–2.33 |
SARS | NLPR3 rs10157379 CT | 0.469 | 0.190 | 6.13 | 0.013 | 1.60 | 1.10–2.32 | |
NLPR3 rs10754558 GG | 0.523 | 0.246 | 4.50 | 0.034 | 0.60 | 0.37–0.96 | ||
Cough | NLPR3 rs10157379 CC | −0.684 | 0.236 | 8.40 | 0.004 | 0.50 | 0.32–0.80 | |
Runny nose | NLPR3 rs10157379 CC | −0.515 | 0.229 | 5.05 | 0.025 | 0.60 | 0.38–0.94 | |
Neurological | Neurological | NLPR3 rs10157379 CC | −2.043 | 1.022 | 3.99 | 0.046 | 0.13 | 0.02–0.96 |
Sickness symptom complex | Fatigue | NLPR3 rs10754558 CG | −0.601 | 0.182 | 10.86 | 0.001 | 0.55 | 0.38–0.78 |
Myalgia | NLPR3 rs10754558 CG | −0.376 | 0.189 | 3.95 | 0.047 | 0.69 | 0.47–0.99 | |
Loss of appetite | NLPR3 rs10754558 GG | −0.8372 | 0.290 | 8.35 | 0.004 | 0.43 | 0.25–0.76 | |
Headache | NLPR3 rs10754558 CG | −0.401 | 0.198 | 4.12 | 0.042 | 0.67 | 0.45–0.99 |
