Fig. 1: APOE-ε4 significantly modified the spatial topography of Aβ PET as function of CSF Aβ42/40. | Molecular Psychiatry

Fig. 1: APOE-ε4 significantly modified the spatial topography of Aβ PET as function of CSF Aβ42/40.

From: Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts

Fig. 1

A, B Surface and volume rendering in ALFA participants of the Aβ PET statistical probability map resulting from the interaction model. Compared to non-carriers, APOE-ε4 carriers displayed higher SUVRs, for any given level of CSF Aβ42/40, in medial temporal regions including entorhinal cortex and hippocampus. C Group scatterplots in ALFA participants showing the significant interaction between APOE-ε4 and CSF Aβ42/40 in a priori defined progressive ROIs. D, E Surface and volume rendering in ADNI participants, of Aβ PET statistical probability map indicating that compared to non-carriers, APOE-ε4 carriers displayed higher SUVRs, for any given level of CSF Aβ42/40, in right inferior and middle temporal as well as right insula. F Group scatterplots in ADNI participants showing the significant interaction between APOE-ε4 and CSF Aβ42/40 in a priori defined progressive ROIs. LL Left lateral, LM Left medial, RL Right lateral, RM Right medial.

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