Fig. 3: Correlations between relative regional volumes of motor, limbic, and associative loops and between relative striato-cerebellar volumes and behavioral metrics of the open field test in DAT-KO rats. | Molecular Psychiatry

Fig. 3: Correlations between relative regional volumes of motor, limbic, and associative loops and between relative striato-cerebellar volumes and behavioral metrics of the open field test in DAT-KO rats.

From: Dopamine transporter silencing in the rat: systems-level alterations in striato-cerebellar and prefrontal-midbrain circuits

Fig. 3

A Pearson’s correlation coefficients between relative regional volumes in DAT-KO rats. Negative correlation coefficients are marked in blue, positive correlation coefficients in red. Volume of the dorsal striatum was anti-correlated with cerebellar volume, while orbitofrontal, motor and cingulate volumes were positively correlated with each other and anti-correlated with subcortical volumes of the ventral tegmental area and the substantia nigra. B Pearson’s correlation coefficients of the DAT-KO group between regional volume in the striato-cerebellar axis and behavioral metrics in the open field test. Striatal volume showed strong negative correlation with distance traveled and positive with center time, while cerebellar regions displayed an opposite pattern. Cb GL granular layer of the cerebellum, Cb ML molecular layer of the cerebellum, Cing1 cingulate cortex area 1, DLT dorsolateral thalamus, dStr dorsal striatum, M1 primary motor cortex, M2 secondary motor cortex, MDT mediodorsal thalamus, OFC orbitofrontal cortex, PLT posterolateral thalamus, SN substantia nigra, STN subthalamic nucleus, TBV total brain volume, VMT ventromedial thalamus, VTA ventral tegmental area. *p < 0.05; **p < 0.01; ***p < 0.001.

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