Fig. 5: Myo-inositol levels in the prefrontal cortex of DAT-KO rats and correlation of myo-inositol to graph metrics. | Molecular Psychiatry

Fig. 5: Myo-inositol levels in the prefrontal cortex of DAT-KO rats and correlation of myo-inositol to graph metrics.

From: Dopamine transporter silencing in the rat: systems-level alterations in striato-cerebellar and prefrontal-midbrain circuits

Fig. 5

A A typical point-resolved spectroscopy spectrum acquired from the prefrontal cortex of one of the rats in the current study and overlaid by the LC Model fit curve. Peak resonances are shown for N-acetylaspartate (NAA), total creatine (Cr), total choline (Cho), myo-inositol (mI), glutamate (Glu), glutamine (Gln), combined glutamate and glutamine (Glx), gamma-aminobutyric acid (GABA) and tau (Tau). B The voxel localization in our study covered predominantly cingulate and prelimbic areas in the left and right hemispheres. C Myo-inositol exhibited significantly higher levels in DAT-KO compared to WT rats. D Partial correlation (with isoflurane as covariate) of myo-inositol with global graph metrics (small-world propensity and robustness against targeted attacks). E–F Partial correlation (with isoflurane as a covariate) of myo-inositol with degree and participation index (PI) of cingulate and prelimbic areas. For brain regions abbreviations see Fig. 3, for other abbreviations see Fig. 4. ppm parts per million. *p < 0.05.

Back to article page