Fig. 4: Prominent changes in GMV focusing in frontal, hippocampal and cerebellar regions of Shank1 R882H-KI HOM mice. | Molecular Psychiatry

Fig. 4: Prominent changes in GMV focusing in frontal, hippocampal and cerebellar regions of Shank1 R882H-KI HOM mice.

From: A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling

Fig. 4

Structural MRI with T2-weighted images revealed the GMVs of multiple brain regions significantly increased in Shank1 R882H-KI HOM mice compared with WT mice. Of these regions, the frontal cortex, hippocampus and cerebellar cortex showed dramatically increased GMVs dramatically increased GMV in frontal cortex (FC), hippocampus (HP) and cerebellar cortex (CBC) in Shank1 R882H-KI HOM mice. Piriform area has the frontal and temporal components. Septal area is the part of the frontal lobe. Voxel-based morphometry (VBM) analysis of brain coronal sections on an averaged MRI template by comparing Shank1 R882H-KI HOM mice (n = 8) with WT mice (n = 9) (P < 0.05, clusters >200 voxels, uncorrected, then followed by FDR correction with significance of 0.05).

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