Fig. 5: Stimulated HPA axis reactivity in Fkbp5-humanised females is greater than in males. | Molecular Psychiatry

Fig. 5: Stimulated HPA axis reactivity in Fkbp5-humanised females is greater than in males.

From: Impact of Fkbp5 × early life adversity × sex in humanised mice on multidimensional stress responses and circadian rhythmicity

Fig. 5

Individual animal data are shown alongside with the mean ± 95% confidence intervals (black) to indicate statistical differences among subgroups. Selected results at group level are indicated. Descriptive statistics, model summaries, and ANOVA results are provided in the Supplementary Tables 1 and 7-10. Acute responsiveness of the HPA axis assessed by comparison of plasma corticosterone levels before and five minutes after restraint stress in females (a) and males (b). Stress induced an increase in corticosterone (p < 1−5) with females responding more than males (p < 1−5). Overall, females vs. males (p < 1−5) and mice with ELA vs. controls had higher corticosterone levels (p = 0.04). Suppression of endogenous corticosterone production six hours after dexamethasone injection (p < 1−5) was more pronounced in females (c) than males (d, p < 1−5).

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