Fig. 3: Increased endogenous GDNF results in behavioural abnormalities. See also Supplementary Fig. S3. | Molecular Psychiatry

Fig. 3: Increased endogenous GDNF results in behavioural abnormalities. See also Supplementary Fig. S3.

From: Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia

Fig. 3

A Pre-pulse inhibition test showing the percentage of inhibition across four different intensities of pre-pulse stimulus. Mean ± SEM. N = 6–7 mice per group. Two-way ANOVA. ***p < 0.001 genotype effect. B Startle response (arbitrary units) in response to a 120 dB stimulus. Mean ± SEM. N = 6–7 mice per group. Welch’s t-test. n.s, not significant. C Average home cage activity, measured as distance travelled, in individually housed Gdnf wt/wt;Nestin-Cre and Gdnf cHyper/cHyper;Nestin-Cre mice over 4 days. Shaded area denotes dark period (lights off), corresponding to the active period in mice. Gdnf cHyper/cHyper;Nestin-Cre mice lack the initial activity peak observed in wild-type littermate controls. Mean ± SEM. N = 13–19 mice per group. Two-way repeated measures ANOVA, Time × Genotype interaction p < 0.0001. Sidak’s multiple comparisons test. **p < 0.01; ***p < 0.001. D Daily water intake in individually housed Gdnf wt/wt;Nestin-Cre and Gdnf cHyper/cHyper;Nestin-Cre mice. Mean ± SEM. N = 7–8 mice per group. Two-way repeated measures ANOVA, Genotype effect p = 0.0371. Sidak’s multiple comparisons test. *p < 0.05. E Average water intake in individually housed Gdnf wt/wt;Nestin-Cre and Gdnf cHyper/cHyper;Nestin-Cre mice over 4 days. Mean ± SEM. N = 7–8 mice per group. Welch’s t-test. *p < 0.05. F Number of visits to water bottle compartments during the dark period in individually tracked mice in the IntelliCage setting. Note that unlike Gdnf wt/wt;Nestin-Cre mice, Gdnf cHyper/cHyper;Nestin-Cre mice do not exhibit reduced activity towards the end of the active (dark) period. Mean ± SEM. N = 9–14 mice per group. Two-way repeated measures ANOVA, Genotype effect p < 0.0001. Sidak’s multiple comparisons test. *p < 0.05; **p < 0.01; ***p < 0.001. G Total number of visits to water bottle compartments in individually tracked mice in the IntelliCage group-housed setting over 4 days. Mean ± SEM. N = 9–14 mice per group. Welch’s t-test. ***p < 0.001.

Back to article page