Table 3 Correlations between individual immunomarkers and cognition in mood and psychotic disorders.

From: The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis

Test	k	N	r	95% CI	z	p	Q test	Q test (p)	I²
CRP
Global cognitive performance	22	25,948	−0.124	−0.185 to −0.062	−3.902	<0.001*	98.89	<0.001	79.78
Verbal memory	16	2304	−0.129	−0.203 to −0.053	−3.322	0.001*	45.03	<0.001	66.69
Visual memory	7	24,160	−0.108	−0.178 to −0.036	−2.960	0.003*	22.55	0.001	73.39
Working memory	10	1133	−0.123	−0.181 to −0.065	−4.109	<0.001*	7.97	0.538	0.00
Attention	14	227,274	−0.065	−0.142 to 0.012	−1.660	0.097	93.39	<0.001	86.08
Processing speed	11	1553	−0.056	−0.123 to 0.012	−1.620	0.105	16.13	0.096	38.01
Reasoning	14	1843	−0.082	−0.152 to −0.010	−2.239	0.025*	26.42	0.015	50.79
Language	8	1644	−0.151	−0.271 to −0.026	−2.364	0.018*	43.58	<0.001	83.94
IL-1b
Global cognitive performance	10	988	−0.083	−0.170 to 0.006	−1.822	0.068	15.48	0.079	41.85
Verbal memory	6	731	−0.105	−0.311 to 0.111	−0.950	0.342	38.71	<0.001	87.08
Visual memory	3	256	−0.245	−0.542 to 0.108	−1.368	0.171	13.28	0.001	84.94
Working memory	5	569	0.092	−0.102 to 0.279	0.925	0.355	17.81	0.001	77.53
Attention	5	389	−0.014	−0.139 to 0.110	−0.225	0.822	5.59	0.232	28.46
Processing speed	7	724	−0.095	−0.253 to 0.068	−1.140	0.254	25.50	<0.001	76.47
Reasoning	6	350	−0.142	−0.298 to 0.022	−1.698	0.090	18.11	0.003	72.40
Language	4	499	−0.035	−0.290 to 0.224	−0.263	0.793	19.07	<0.001	84.27
IL-6
Global cognitive performance	27	2250	−0.167	−0.259 to −0.072	−3.431	0.001*	119.99	<0.001	78.33
Verbal memory	18	1776	−0.131	−0.245 to −0.013	−2.181	0.029	96.98	<0.001	82.47
Visual memory	5	469	−0.016	−0.140 to 0.109	−0.247	0.805	6.32	0.176	36.72
Working memory	14	1200	−0.086	−0.192 to 0.022	−1.555	0.120	34.23	0.001	64.95
Attention	12	1013	−0.021	−0.128 to 0.085	−0.392	0.695	27.44	0.004	59.9
Processing speed	13	1266	−0.132	−0.211 to −0.051	−3.202	0.001*	18.12	0.079	39.28
Reasoning	16	1335	0.002	−0.089 to 0.093	0.037	0.971	35.06	0.002	57.22
Language	10	1179	−0.100	−0.213 to 0.014	−1.714	0.087	30.62	<0.001	70.60
TNF-a
Global cognitive performance	23	1868	−0.028	−0.077 to 0.021	−1.119	0.263	23.75	0.360	7.37
Verbal memory	14	1280	−0.016	−0.108 to 0.077	−0.331	0.740	31.98	0.002	59.35
Visual memory	5	326	−0.081	−0.190 to 0.030	−1.437	0.151	3.23	0.520	0.00
Working memory	13	1017	−0.098	−0.197 to 0.002	−1.917	0.055	25.85	0.011	53.58
Attention	10	732	0.034	−0.103 to 0.169	0.482	0.630	26.89	0.001	66.53
Processing speed	14	1178	−0.020	−0.143 to 0.105	−0.307	0.759	45.54	<0.001	73.65
Reasoning	20	1619	0.019	−0.066 to 0.105	0.445	0.656	47.05	<0.001	59.62
Language	7	764	−0.004	−0.153 to 0.144	−0.057	0.955	20.92	0.002	71.32
IFN-g
Global cognitive performance	5	203	0.055	−0.112 to 0.219	0.647	0.517	5.04	0.284	20.59
Verbal memory	4	187	0.060	−0.088 to 0.205	0.792	0.428	2.37	0.500	0.00
Working memory	3	127	0.035	−0.274 to 0.337	0.216	0.829	5.12	0.077	60.93
Attention	3	97	−0.144	−0.397 to 0.129	−1.033	0.302	2.65	0.266	24.39
Reasoning	4	158	0.062	−0.103 to 0.223	0.732	0.464	3.08	0.380	2.46

K number of studies, N total number of participants, r mean effect size of correlation.
*Statistically significant after Benjamini–Hochberg procedure correction.

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Table 3 Correlations between individual immunomarkers and cognition in mood and psychotic disorders.

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