Fig. 1: Brain regions involved in the social and/or cognitive domain.

The depicted brain regions are involved in the social domain (red), cognitive domain (blue), or in both domains (purple). A A sagittal illustration of the rodent brain showing our identified brain regions and their involvement in the social and/or cognitive domain. Several connections between brain areas are drawn to illustrate that brain regions act in a network. Image was adapted with permission from Ike et al., Neurosci Biobehav Rev. (2020) [60]. B Human brain indicating brain regions relevant to schizophrenia, major depressive disorder, and/or Alzheimer’s Disease. All these brain regions are involved in both social and cognitive functioning. The image was adapted with permission from Porcelli et al., Neurosci Biobehav Rev. (2019) [36]. ACC anterior cingulate cortex, aHN anterior hypothalamic nucleus, BLA basolateral amygdala, BNST bed nucleus of the stria terminalis, CA cornu ammonis, CE cerebellum, CeA central amygdala, dlPFC dorsolateral prefrontal cortex, DRN dorsal raphe nucleus, EHC entorhinal cortex, FFA fusiform face area, IC insular cortex, IFG inferior frontal gyrus, IL infralimbic cortex, IPL inferior parietal lobule, LC locus coeruleus, LHab lateral habenula, LS lateral septum, Mcx motor cortex, meA medial amygdala, mPFC medial prefrontal cortex, NAc nucleus accumbens, OB olfactory bulb, OFC orbitofrontal cortex, PAG periaqueductal gray, PIR piriform cortex, PL prelimbic cortex, pMv ventral premammilary nucleus, POA medial preoptic area, PVN paraventricular nucleus, RSP retrosplenial area, SOS superior orbital sulcus, SScx somato-sensory cortex, STG superior temporal gyrus, Sub subiculum, Tha thalamus, TPJ temporo-parietal junction, vlPFC ventrolateral prefrontal cortex, VMH ventral medial hypothalamus, VP ventral pallidum, VTA ventral tegmental area.