Table 1 Overview of samples included in GWAS meta-analysis of OUD cases vs. OUD controls.
Cohorts | EUR cases | EUR controls | EUR Neffective | AFR cases | AFR Controls | AFR Neffective | Case definition | Control definitiona |
---|---|---|---|---|---|---|---|---|
MVP 1-2 combined | 8529 | 267,737 | 33,062 | 4032 | 71,511 | 15,265 | ICD-9/ICD-10 | unscreened |
MVP Release 1 | 6367 | 202,636 | 24,692 | 3151 | 54,178 | 11,911 | ||
MVP Release 2 | 2162 | 65,101 | 8370 | 881 | 17,333 | 3354 | ||
PGC-SUDb | 3272 | 25,437 | 11,596 | 1231 | 7063 | 4193 | DSM-IV | unexposed |
Partners Biobank | 1039 | 20,271 | 3953 | - | - | - | ICD-9/ICD-10 | no SUD diagnosis |
BioVU | 933 | 3,732 | 2,986 | - | - | - | ICD-9/ICD-10 | unscreened |
FinnGen | 651 | 214,999 | 2596 | - | - | - | ICD-9/ICD-10 | unscreened |
Yale-Penn 3 | 448 | 1538 | 1388 | 172 | 868 | 574 | DSM-IV | no OUD diagnosis |
iPSYCH | 379 | 5221 | 1413 | - | - | - | ICD-9/ICD-10 | no OUD diagnosis |
Ancestry-specific subtotals | 15251 | 538,935 | 56,994 | 5435 | 79,442 | 20,032 | ||
Overall total cases | 20,686 | |||||||
Overall total controls | 618,377 | |||||||
Overall total N | 639,063 | Total Neffective | 77,026 | |||||
EUR total N | 554,186 | EUR Neffective | 56,994 | |||||
AFR total N | 84,877 | AFR Neffective | 20,032 |