Table 1 Meta-analyses results of lead SNPs for verbal short-term memory, paragraph recall, and verbal learning in discovery, replication, and combined samples (N = 53,637).
From: Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
Discovery cohorts | Replication cohorts | Discovery + Replication cohorts | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pheno-type | SNP | Chr | Genomic position | EA/OA | EAF | Nearby gene | Predicted function | N | Z-score | P-val | Direction | Het P-val | N | Z-score | P-val | Direction | Het P-val | Na | Z-score | P-val |
VL | rs4687625 | 3 | 52538758 | t/c | 0.38 | NT5DC2 | Intronic | 28579 | 5.70 | 1.2E−08 | +?+++++++++++−++++++++ | 0.97 | 3853 | 2.74 | 0.006 | ++ | 0.28 | 32432 | 6.3 | 3.1E−10 |
VL | rs2015971 | 3 | 52521860 | t/c | 0.38 | STAB1 | Intronic | 28127 | 5.64 | 1.7E−08 | +?−+++?++++++−++++++++ | 0.96 | 3853 | 2.70 | 0.007 | ++ | 0.23 | 31980 | 6.2 | 4.8E−10 |
VL | rs11711421 | 3 | 52536819 | t/c | 0.39 | NT5DC2 | Intronic | 28579 | 5.53 | 3.3E−08 | +?−++++++++++−++++++++ | 0.96 | 3853 | 2.55 | 0.01 | ++ | 0.29 | 32432 | 6.1 | 1.3E−9 |
VL | rs2276816 | 3 | 52835856 | t/c | 0.12 | ITIH4 | Synon | 27896 | 5.53 | 3.3E−08 | +++++++++−+−+?++++++++ | 0.53 | 3067 | 0.61 | 0.54 | ?+ | 1 | 30963 | 5.4 | 5.4E−8 |
VSTM | rs425724 | 5 | 19518050 | c/t | 0.12 | CDH18 | Intronic | 44668 | 5.56 | 2.7E−08 | ?++++++++−−+++++++++++++++− | 0.67 | 8763 | 2.04 | 0.04 | +++++ | 0.84 | 53431 | 5.91 | 3.4E−09 |
VSTM: Paragraph | rs9528369 | 13 | 62216927 | a/c | 0.32 | Intergenic | 18098 | −6.0 | 2.0E−09 | ?−−−−−−??−−−+ | 0.62 | 4293 | −0.79 | 0.43 | −+− | 0.66 | 22391 | −5.74 | 9.4E−9 | |
VSTM | rs4420638 | 19 | 45422946 | g/a | 0.18 | APOC1 | 3’down-stream | 37556 | −7.23 | 4.9E−13 | ?+−−−−−?−−−−−−??−?−−−−+−?−− | 5.5E−05 | 8164 | −2.89 | 0.004 | −−?−+ | 1.4E−04 | 44317 | −7.83 | 4.9E−15 |
VL | −“− | −“− | −“− | −“− | −“− | −“− | −“− | 23575 | −7.05 | 1.8E−12 | −?+−−−−?−−−?−?−−−−−−+? | 0.14 | 3067 | 0.56 | 0.58 | ?+ | 1 | 26642 | −6.4 | 1.2E−10 |
VSTM: Paragraph | −“− | −“− | −“− | −“− | −“− | −“− | −“− | 16216 | −6.93 | 4.2E−12 | ?−−−−?−?−−−−− | 4.4E−05 | 3694 | −5.14 | 2.78E−07 | −?− | 0.37 | 19910 | −8.47 | 2.5E−17 |
VL: Visual | −“− | −“− | −“− | −“− | −“− | −“− | −“− | 15096 | −6.0 | 3.1E−09 | −−?−−−−−−−+ | |||||||||
VL | rs6857 | 19 | 45392254 | t/c | 0.16 | PVRL2 | 3’utr | 26849 | −6.00 | 2.0E−09 | −?−−−−−?−−−+−?−−−−−−++ | 2.2E−05 | 3067 | 0.63 | 0.53 | ?+ | 1 | 29916 | −5.5 | 4.2E−8 |
