Fig. 3: Change in anhedonia scores negatively correlated with VS-vmPFC rsFC after L-DOPA challenge only in patients with CRP > 2 mg/L. | Molecular Psychiatry

Fig. 3: Change in anhedonia scores negatively correlated with VS-vmPFC rsFC after L-DOPA challenge only in patients with CRP > 2 mg/L.

From: Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study

Fig. 3

An interaction was observed for treatment and CRP level on the relationship between rsFC and change in anhedonia (SHAPS scores, post minus pre), whereby a decrease in anhedonia was correlated with VS-vmPFC rsFC after L-DOPA but only in patients with CRP > 2 mg/L. CRP C-reactive protein, FC functional connectivity, L-DOPA levodopa, SHAPS Snaith-Hamilton Pleasure Scale, rs resting state, vmPFC ventromedial prefrontal cortex, VS ventral striatum.

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