Fig. 3: Reactive astrocyte biomarkers mediate the effect of AD pathophysiology on downstream neurodegeneration and cognitive impairment.
From: Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease
The figure shows the standardized structural equation model estimates of the associations between A CSF GFAP and B CSF YKL-40 levels, hippocampal volume, and cognition. Solid black lines represent significant associations, whereas dashed gray lines represent non-significant effects. The fact that the presented estimates are standardized allows direct comparison between effects. Aβ pathology was measured with neocortical Aβ-PET SUVR and tau pathology using temporal meta-ROI tau-PET SUVR. Cognition was indexed using the MMSE score. All associations were further adjusted for age, APOE ε4 status, and years of education. NS not significant.
