Fig. 4: Effects of Aβ1-6A2V(D) on amyloid burden (densitometric analysis).
From: A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer’s disease
Neuropathological study on mice intranasally treated with Aβ1-6A2V(D) every 48 h for 5 months Quantification of the effects of the treatment on amyloid burden was achieved by a densitometric analysis based on ‘plaque count’ in the two experimental groups: saline-treated animals (blue columns, n = 10) and Aβ1-6A2V(D)-treated mice (red columns, n = 10). Amyloid burden was strongly decreased in the group treated with Aβ1-6A2V(D) in comparison with mice treated with saline solution (control group) in several brain areas (motor cortex, somatosensory cortex, entorhinal cortex, thalamus, hippocampus, olfactory bulbs). The significance of the results was calculated using a Mann–Whitney U test. Statistical differences were considered significant if p < 0.05.
