Fig. 2: Reduced hippocampal cell excitability in TRPC6 KO mice. | Molecular Psychiatry

Fig. 2: Reduced hippocampal cell excitability in TRPC6 KO mice.

From: Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs

Fig. 2

Whole-cell current-clamp recordings were performed from hippocampal CA1 pyramidal cells and dentate gyrus granule cells in brain slice preparation. Action potentials (APs) were evoked with a depolarizing ramp pulse from 0 to 100 pA for 2 s from resting membrane potential (RMP) or −70 mV (adjusted by current injection). A Voltage traces from CA pyramidal cells from a WT and a TRPC6 KO slice illustrate the evoked APs. The dashed line indicates −70 mV and the gray lines below show the ramp protocol. Histograms summarize the number of APs per ramp (B) and the rheobase (the minimal current necessary to elicit first AP; C in WT and TRPC6 KO hippocampal cells. *p < 0.05; **p < 0.01.

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