Table 3 Regression models of the significant mutually adjusted interactions between ACEs and hair cortisol for depression, anxiety, and loneliness.

From: The relationship of adverse childhood experiences, hair cortisol, C-reactive protein, and polygenic susceptibility with older adults’ psychological distress during the COVID-19 pandemic

Term

Estimate (OR/b)

Standard error

P value

FDR adjusted p-value

Confidence low

Confidence high

Depression1,2

      

Total ACEs

1.054

0.091

0.566

0.777

0.878

1.258

Hair cortisol

1.060

0.065

0.369

0.633

0.931

1.200

ACEs*Cortisol

1.069

0.034

0.048

0.156

1.001

1.142

Anxiety1,2

      

Total ACEs

0.814

0.134

0.123

0.329

0.621

1.050

Hair cortisol

0.872

0.107

0.203

0.471

0.703

1.071

ACEs*Cortisol

1.166

0.049

0.002

0.012

1.060

1.283

Loneliness2

      

Total ACEs

0.015

0.039

0.701

0.818

−0.061

0.090

Hair cortisol

−0.043

0.024

0.074

0.214

−0.090

0.004

ACEs*Cortisol

0.039

0.015

0.012

0.058

0.008

0.069

  1. 1Odds ratios are presented for anxiety and depression.
  2. 2Covariates included in the models: pre-pandemic psychological distress (depression, anxiety, and loneliness), adult sociodemographic factors (age, gender, partnership status, living alone, wealth tertiles), use of medication (anti-inflammatory/antihypertensive drugs, steroids), childhood socioeconomic factors (overcrowding, number of books in home, financial hardship, parent unemployment), hair characteristics (dyed, colour, season of collection, phase of hair analysis), and genetic population stratification by including 10 principal components.
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