Fig. 5: STAT1 can regulate a large number of inflammatory mediators in interferon signaling pathways. | Molecular Psychiatry

Fig. 5: STAT1 can regulate a large number of inflammatory mediators in interferon signaling pathways.

From: Single cell transcriptomics reveals distinct transcriptional responses to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder

Fig. 5

A protein-protein interaction network of genes shown in Fig. 4A was constructed by using the STRING database (https://string-db.org/). The number of lines indicates the strength of predicted functional interactions between the proteins using a Markov Cluster Algorithm. The color of the lines connecting the nodes indicates the particular lines of evidence used to establish a functional association. There is no particular meaning of the node color itself because they are used only as a visual aid. The distance between the nodes is a measure of the confidence of the interaction as determined by a Bayesian scoring system. B iPSC-derived neurons (n = 3) were used to determine relative mRNA expression of genes shown in Fig. 4A in response to STAT1 inhibitor that ranged from 2.5 µM to 20 µM.

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