Fig. 6: LPS and inflammatory cytokines mediate the association between the gut microbiota and depressive-like behavior.

a Correlation between the gut microbiota. b Correlation between LPS and inflammatory cytokines. c Estimated −log10(p values) of natural indirect effects from pairwise weighted mediation models (the mediation model is shown in Fig. S14) for depressive-like behavior. The dashed vertical line signifies a p value threshold of 0.05, and the points on the right side of the line estimates are below that threshold. Overlapping points have been labeled.