Table 1 Effect of test drugs on DAT and SERT-mediated uptake.
From: Serotonin-releasing agents with reduced off-target effects
IC50 (µM) (95% CI in brackets) | |||
|---|---|---|---|
DAT | SERT | DAT/SERT ratio | |
S-MC | 9.1 (6.98–11.67) | 392.8 (306.3–503.6) | 43.2 |
R-MC | 10.62 (6.88–16.6) | 963.7 (700.6–1332) | 90.7 |
S-4-MMC | 10.3 (6.74–16.00) | 10.87 (9.18–12.93) | 1.06 |
R-4-MMC | 12.5 (6.84–23.78) | 77.06 (59.63–100.2) | 6.2 |
S-4-MC | 6.65 (5.83–7.61) | 12.63 (11.22–14.23) | 1.9 |
R-4-MC | 9.6 (8.1–11.41) | 185.7 (166.3–207.6) | 19.3 |
S-4-TFMMC | 190.5 (120.7–310.7) | 10.22 (7.9–13.34) | 0.05 |
R-4-TFMMC | 153.1 (112.7–210.9) | 22.64 (19.24–26.7) | 0.15 |
