Fig. 4: Strategies for modeling neurodevelopmental perturbations in human brain organoids.
From: Neurodevelopmental disorders—high-resolution rethinking of disease modeling
A Overview of different strategies to model neurodevelopmental perturbations in vitro in human cellular systems, including brain organoids. B When an organoid model is deemed adequate for modeling a neurodevelopmental perturbation, careful consideration should be made concerning the protocol that is most suitable for the given research question instead of applying a “one size fits all” approach to organoid modeling. Single-cell and spatial omics datasets are then a crucial resource that can help us evaluate the protocol that is most adequate for modeling a given developmental perturbation.
