Fig. 4: Cohen’s d effect sizes in early-onset psychosis (EOP) and adult schizophrenia (SCZ) relative to healthy controls from a prior publication1.

A Meta-analytically derived effect sizes for tract-specific fractional anisotropy (FA) in EOP relative to healthy controls and in adult schizophrenia relative to healthy controls. B Mega-analytically derived effect sizes for tract-specific FA in EOP relative to healthy controls and meta-analytically derived effect sizes in adult schizophrenia relative to healthy controls. C Correlation in meta-analytically derived effect sizes of tract-specific FA between EOP and adult schizophrenia. D Correlation in mega- and meta-analytically derived effect sizes of tract-specific FA between EOP and adult schizophrenia, respectively. In both EOP and SCZ, meta-analytic results were adjusted for age, sex, and linear and nonlinear age and sex interactions (age-by-sex interaction, age [2], and age [2]-by-sex interaction). Cohen’s d values and their standard errors are displayed. SK provided values for SCZ.