Fig. 1: Experimental flowchart.

A MayoRNAseq comprise individuals with matched genetic (WGS) and gene-expression data (bulk brain RNA-seq) from two brain regions: cerebellum and temporal cortex. B Differentially expressed genes were derived separately for case/controls and PRS. C Gene-ontology enrichment analysis was performed separately for both case/control and PRS outcomes and compared pairwise across all analyses.