Fig. 4: Semantic similarity clustering of up and down-regulated statistically significant GO terms in temporal cortex (case/control vs. PRS analysis). | Molecular Psychiatry

Fig. 4: Semantic similarity clustering of up and down-regulated statistically significant GO terms in temporal cortex (case/control vs. PRS analysis).

From: Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer’s disease through polygenic risk and RNA sequencing

Fig. 4

A Semantic similarity clustering (BP only up-regulated GO). B Overlap of GO terms (BP, CC and MF up-regulated GOs). C Semantic similarity clustering (BP only down-regulated GO). D Overlap of GO terms (BP, CC and MF down-regulated GOs). A, C X-and Y-axes represent classical multidimensional scaling (CMD) dimension 1 and 2. All GO terms p ≤ 0.05 FDR. Green dots represent significant GO terms from the case/control & PRS analysis of temporal cortex, blue dots represent significant GO terms from the case/control & PRS analysis of temporal cortex, red dots represent significant GO terms overlapping in case/control analysis of cerebellum and temporal cortex. Cluster labels were manually curated based on the most common GO term in the cluster. B, D Proportional Venn diagram. Numbers represent the significant GO terms (FDR) in the two lists with the middle number representing the number of GOs that overlap. Red colour represents case/control the blue PRS analyses. hypergeometric test for (B) p < 1.0 × 10−300 hypergeometric test for (D) p = 3.04 × 10−93.

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