Fig. 5: Characterization of inflammatory diet proteins linked to incident cognitive impairment.

A Consensus transcript expression levels (normalized Transcripts per Million; nTPM) across immune tissues of interest based on transcriptomics data from the Human Protein Atlas and Genotype-Tissue Expression project. B Results from nine different RNA-seq analyses across four different immune cell types which reported differential expression of genes encoding candidate proteins in response to treatment with lipopolysaccharide (LPS), an immune challenge. C Protein-protein interaction network analyses were generated using STRING^©; predicted protein conformations are depicted in each protein’s circular node. GO enrichment analysis for biological processes and molecular functions utilized PANTHER™ functional classification platform. D Summary of evidence, including results linking candidate proteins to data obtained from AMP®-AD. Accelerating Medicines Partnership for Alzheimer’s Disease AMP®-AD, eQTL expression quantitative trait loci, DEG differentially expressed gene, LPS lipopolysaccharide; normalized Transcripts per Million, nTPM Protein Analysis Through Evolutionary Relationships Classification System, PANTHER™ Search Tool for the Retrieval of Interacting Genes/Proteins, STRING^©.