Fig. 1: Allelic spectrum of schizophrenia-associated variants. | Molecular Psychiatry

Fig. 1: Allelic spectrum of schizophrenia-associated variants.

From: The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research

Fig. 1

A plot of minor allele frequencies in controls (x-axis) and ORs (y-axis) for schizophrenia-associated genes/variants with robust statistical evidence, that is, the index SNPs of 287 genome-wide significant loci identified by the PGC GWAS (blue, ref. [20]), ten exome-wide significant genes in the SCHEMA exome sequencing study (green, ref. [21]) and the study-wide significant eight CNVs in the PGC CNV Working Groups study (red, ref. [31]). Genes and variants with OR > 1.2 were labeled. The sizes of points are proportional to the −log10 P values for the association. The error bars indicate 95% confidence intervals of the ORs. The upper right chronology summarizes the representative studies of etiologically valid mouse and cellular models of schizophrenia shown in Tables 2 and 3.

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