Fig. 3: PNN components and metalloproteases are expressed by different cell types in mouse PFC. | Molecular Psychiatry

Fig. 3: PNN components and metalloproteases are expressed by different cell types in mouse PFC.

From: Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories

Fig. 3

a Single cell RNA-sequencing (DropSeq) of PFC cells of P40-43 wild-type mice (n = 8 mice). t-SNE visualization of identified cell types; cluster 9 refers to PV+ cells. b–d Expression localization of critical components of PNN structure and remodeling, including lecticans (b Acan, Bcan, Ncan, and Vcan), metalloproteases known to be expressed by PV+ cells (c Adamts8, Adamts15, and Mme) and other critical PNN components (d Halpn1, Halpn4, and Tnr).

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