Fig. 3: Causal inference between brain age gap and disorders.
From: Genetic architecture of brain age and its causal relations with brain and mental disorders
a Causal effect of brain age gap (BAG) on risk of disorders; b Causal effect of genetic risk of disorders on BAG. Colors indicate different models; triangle indicates significant effect after false discovery correction. Estimated standard errors for each effect are aslo shown. c Scatter plots of SNP effects on AD (x axis) and BAG (y axis). d Scatter plots of SNP effects on BIP (x axis) and BAG (y axis). e Scatter plots of SNP effects BAG (x axis) and PD (y axis). f Scatter plots of SNP effects on PD (x axis) and BAG (y axis). Causal effects estimated by the five models (except CAUSE) are shown by fitted lines; slopes of these lines indicate causal effect sizes. Exceptional SNPs are marked by boxes that include SNP rs-numbers and genome location in the hg19 coordinates. AD Alzheimer’s disease, BIP bipolar disorder, MDD major depression disorder, PD Parkinson’s disease, SCZ schizophrenia.
