Fig. 1: Schematic showing 2N4R tau (441 amino acids), the longest isoform expressed encompassing major structural domains. | Molecular Psychiatry

Fig. 1: Schematic showing 2N4R tau (441 amino acids), the longest isoform expressed encompassing major structural domains.

From: Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials

Fig. 1

The phosphosites identified for AD pathology (in red), physiology (in green) and overlapping sites for both physiology and pathology (in purple) are shown here. Therapeutically targeted protein kinases (PKs) and protein phosphatase (PPs) are colour coded to their respective inhibitors or modulators explored clinically or preclinically.

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