Fig. 3: FAD cultures manifest enhanced neuronal excitability. | Molecular Psychiatry

Fig. 3: FAD cultures manifest enhanced neuronal excitability.

From: 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease

Fig. 3

A Representative traces of spontaneous LFPs (mV) obtained from 3D cultures derived from a FAD line (hFAD-2 Clone B) and the isogenic control (C-hFAD-2 Clone B) at 2 months and 4.5 months. A 20-s reference is provided for traces. Quantification of normalized spontaneous and evoked LFP spikes/min (Log10) at 2 months (B) and 4.5 months (C). FAD cultures (hFAD-1, hFAD-2 Clone A, hFAD-2 Clone B) and controls (C-hFAD-2 Clone B, BR24, YZ1) plotted as groups are provided. B Spontaneous CTR 2 mo n = 26, FAD 2 mo n = 25. Evoked CTR 2 mo n = 26, FAD 2 mo n = 25. C Spontaneous CTR 4.5 mo n = 23, FAD 4.5 mo n = 21. Evoked CTR 4.5 mo n = 22, FAD 4.5 mo n = 21. Unpaired t-test.

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