Fig. 4: Differential expression and functional analysis of the NanoString panel in FAD cultures. | Molecular Psychiatry

Fig. 4: Differential expression and functional analysis of the NanoString panel in FAD cultures.

From: 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease

Fig. 4

DEGs (absolute fold change > 1.5, FDR < 0.05) in 2-month (A) and 4.5-month (B) CTR and FAD lines are shown in the heatmap. GSA of differentially expressed genes in iPSC-derived cultures (FAD vs. CTR, ROSALIND® platform, NanoString annotations) at 2 months (C) and 4.5 months (D). Upregulation: directed enrichment score > 0. Downregulation: directed enrichment score < 0. FAD 2 mo n = 8, CTR 2 mo n = 8, FAD 4.5 mo n = 9, CTR 4.5 mo n = 7.

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