Fig. 3: A potential role for PV neurons in shaping memory-specific neuronal ensembles.
From: Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer’s disease
A PV neurons shape memory engrams by preventing excessive activation of pyramidal cells. They thus control the size of an engram and contribute to the storage and recall of specific memories. B When PV neuron activity is increased, pyramidal cells receive too much inhibition during memory allocation, and smaller engrams are formed. This would hypothetically result in weaker memories. C When PV neuron activity is decreased, too many pyramidal cells are recruited in memory engrams, which would hypothetically lead to larger engrams and generalization of memories. It is important to note that in addition to PV cells, other interneurons have also been shown to play a crucial role in shaping neuronal memory ensembles (see main text for details).
