Fig. 2: Developmental loss of DAergic neurons in Wnt1sp/sp rats. | Molecular Psychiatry

Fig. 2: Developmental loss of DAergic neurons in Wnt1sp/sp rats.

From: A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats

Fig. 2

A Th immunofluorescence staining of brain sections of WT (n = 3) and Wnt1sp/sp rats (n = 3) at P28. B Quantitative analyses of (A). C Th immunohistochemical staining of the striatum in WT (n = 3) and Wnt1sp/sp rats (n = 3) at P28. D Western blot shows the expression of Th in the midbrain (n = 10) and striatum (n = 7). E Quantitative analyses of (D). F The left panel (from Baless and Ang [56]) shows the position of the coronal section as well as where the picture is zoomed in the right panel. The immunofluorescence staining of brain sections of WT (n = 3) and Wntsp/spWnt1sp/sp rats (n = 3) at E12.5 with Aldh1a1 or Th. G Quantitative analyses of the staining signals in (F). All data are expressed as mean ± SEM. **p < 0.01; ***p < 0.001, Student’s t test.

Back to article page