Fig. 5: DA replacement therapy (DA-RT) largely rescued ASD-like behaviors in Wnt1sp/sp rats. | Molecular Psychiatry

Fig. 5: DA replacement therapy (DA-RT) largely rescued ASD-like behaviors in Wnt1sp/sp rats.

From: A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats

Fig. 5

A Schematic paradigm for DA-RT. B DA and its metabolites in the striatum (n = 5–10). C Total call counts and call duration in USV test. WT (n = 9–13) and Wnt1sp/sp (n = 8–13) rats at P11 were used. D Left panel is the trajectory diagram, and right bar figure shows the time spent in each chamber. WT (n = 11–13) and Wnt1sp/sp rats (n = 7–11) were examined. E–I Open-field test. E Total distance traveled. F Distance traveled in the central area. G Time spent in the central area. H Number of rotations. I Trajectory diagram of the test: the central area (blue square) and the peripheral area (the other parts). WT (n = 7–12) and Wnt1sp/sp rats (n = 7–13) were examined. Data are expressed as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001, Student’s t test.

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