Fig. 2: Differential enrichment of synaptic proteins between NAc and DLPFC associated with OUD. | Molecular Psychiatry

Fig. 2: Differential enrichment of synaptic proteins between NAc and DLPFC associated with OUD.

From: Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens

Fig. 2

Lollipop plot showing pathways enriched from DE proteins in synaptosomes relative to homogenates in a NAc and b DLPFC. Adjusted p value by color. Size of the circle represents counts of proteins within pathways. The enrichment score is calculated as the count of proteins identified as DE in OUD subjects divided by the count of proteins in the background of the respective ontological pathway. Bolded text with stars represents pathways enriched in both brain regions. Bolded only text represents pathways enriched in synaptosomes of the region analyzed. Also see Supplementary Table S11 for Enrichment in NAc Synaptosomes; Supplementary Table S12 for Enrichment in DLPFC Synaptosomes. NAc nucleus accumbens, DLPFC dorsolateral prefrontal cortex.

Back to article page