Fig. 5: Astrocytic expression of amphiregulin raises social rank and increases functional connectivity. | Molecular Psychiatry

Fig. 5: Astrocytic expression of amphiregulin raises social rank and increases functional connectivity.

From: Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse

Fig. 5

a Percentage of cages with mice showing the change in rank after administration of control or GFAP- AREG AAV5 virus in WT and CRTC3 KO mice, 15 cages. b Summary of changes in winning points after infusion, WT (n = 15), KO (n = 15). c Changes in the winning points by each mouse (gray), and the average winning points (red) before and after GFAP- AREG virus infection in CRTC3 KO mice, before (n = 15), after (n = 15). d Time spent in the warm spot (right) by each mouse (gray), and the average points (red) before and after GFAP-AREG virus infection in CRTC3 KO mice, before (n = 17), after (n = 17). e The resting-state functional connectivity matrices of social dominance-related brain ROIs from baseline (left) and GFAP-AREG injection states (middle) in CRTC3 KO mice are represented. The mean difference map is represented (right). f Compared with baseline, GFAP-AREG virus-infected CRTC3 KO mice show also significantly increased mean z-CorrCoef between the ROI groups of the prefrontal cortex (PFC) and posterior parietal cortex (PTLp). Before (n = 19), after (n = 16), Kruskal-Wallis test, Wilcoxon signed rank test, Unpaired t-test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, Error bars, SEM.

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